HydraDAO science

Replacement for
Lifespan Extension

Replacement
for Lifespan Extension

LBF REPLACEMENT ROADMAP

Replacement is an engineering approach to aging that requires fewer fundamental advances in discovery in aging/biology. It focuses on replacing aged body parts with lab-grown or synthetic alternatives, such as organ transplants, cloned tissues and whole-body replacements, aiming to extend lifespan without needing to fully decode aging mechanisms.

SCIENTIFIC FOCUS AREAS

01

Whole body replacement via cloned or synthetic embryo with neocortex knockout for head or brain transplant.

Whole body replacement uses cloned or synthetic embryos with a neocortex knockout, creating non-sentient bodies for head or brain transplants that ensure compatibility and prevent rejection.

Technologies Required

Cloned Non-Sentient Bodies
Body Transplant Process

02

Progressive brain replacement via stemcell-based tissue engineering.

Progressive brain replacement uses stem cell-based tissue engineering to regenerate and restore neural function by gradually integrating lab-grown replacements.

Technologies Required

Progressive Brain Replacement

03

Total replacement of aged body parts with lab-grown young parts.

Total replacement of aged body parts involves using lab-grown, youthful tissue to regenerate limbs and other organs.

Technologies Required

Limb regeneration
Xenotransplantation
Bioprinting

TECHNOLOGIES IN DEVELOPMENT

Progressive Brain Replacement

Replacement of aging brain tissue, minimizing disruption to cognitive function and allowing gradual replacement without loss of identity or memory.

Progressive Brain

Replacement of aging brain tissue, minimizing disruption to cognitive function and allowing gradual replacement without loss of identity or memory.

Body Transplant Process

Advancing the field of transplant surgery, our work focuses on refining surgical techniques for head and brain transplants while also pioneering innovations in spinal cord fusion

Body Transplant Process

Advancing the field of transplant surgery, our work focuses on refining surgical techniques for head and brain transplants while also pioneering innovations in spinal cord fusion

Limb Regeneration

Activation of stem cells and tissue scaffolding to initiate and guide the regrowth of complex tissues. By leveraging growth factors, gene editing, and bio-electricity, we aim to replicate the remarkable regenerative capabilities found in species like axolotls

Limb Regeneration

Cloned Non-Sentient Bodies

Developing and testing gene editing techniques for clone neocortex knockout, striving to achieve a near-zero false-negative knockout rate

Cloned Non-Sentient Bodies

Developing and testing gene editing techniques for clone neocortex knockout, striving to achieve a near-zero false-negative knockout rate

Bioprinting

Scaled production of bioprinted organs using organ-specific bioinks, with a strong focus on ensuring vascularization and seamless functional integration

Bioprinting

Scaled production of bioprinted organs using organ-specific bioinks, with a strong focus on ensuring vascularization and seamless functional integration

Xenotransplantation

Genetic modification of donor animals to prevent rejection and enhance compatibility, alongside developing protocols to induce immune tolerance in human recipients

Xenotransplantation

Genetic modification of donor animals to prevent rejection and enhance compatibility, alongside developing protocols to induce immune tolerance in human recipients

Replacement forLifespan Extension

Replacementfor Lifespan Extension

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Replacement for
Lifespan Extension

Replacement
for Lifespan Extension