Replacement for Lifespan Extension

Replacement is an engineering approach to aging that requires fewer fundamental advances in discovery in aging/biology.


  1. Whole body replacement via cloned or synthetic embryo with neocortex knockout for head or brain transplant.
  2. Progressive brain replacement via stemcell-based tissue engineering.
  3. Total replacement of aged body parts with lab-grown young parts.
LBF Replacement Roadmap

HydraDAO Objectives

Progressive Brain Replacement

  • Replacement of aging brain tissue, minimizing disruption to cognitive function and allowing gradual replacement without loss of identity or memory.

Body Transplant Process

  • Refine surgical techniques for head/brain transplants.
  • Spinal cord fusion.

Limb Regeneration

  • Activation of stem cells and tissue scaffolding to initiate and guide regrowth of complex tissues.
  • Use of growth factors, gene editing and bioelectricity to replicate regenerative capabilities similar to those found in species like axolotls.

Cloned Non-Sentient Bodies

  • Develop and test gene editing for clone neocortex knockout.
  • Achieve near zero false-negative knockout rate.

Bioprinting

  • Scaled production of bioprinted organs using organ-specific bioinks.
  • Ensuring vascularization and functional integration within printed organs.

Xenotransplantation

  • Genetic modification of donor animals to prevent rejection and enhance compatibility.
  • Development of protocols to induce immune tolerance in human recipients.

...and much more.