HydraDAO science
Replacement for
Lifespan Extension
Replacement
for Lifespan Extension
Replacement is an engineering approach to aging that requires fewer fundamental advances in discovery in aging/biology. It focuses on replacing aged body parts with lab-grown or synthetic alternatives, such as organ transplants, cloned tissues and whole-body replacements, aiming to extend lifespan without needing to fully decode aging mechanisms.
FOCUS AREAS / FOCUS AREAS / FOCUS AREAS
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Whole body replacement via cloned or synthetic embryo with neocortex knockout for head or brain transplant.
Whole body replacement via cloned or synthetic embryo with neocortex knockout for head or brain transplant.
Whole body replacement uses cloned or synthetic embryos with a neocortex knockout, creating non-sentient bodies for head or brain transplants that ensure compatibility and prevent rejection.
Cloned Non-Sentient Bodies
Body Transplant Process
01

Whole body replacement via cloned or synthetic embryo with neocortex knockout for head or brain transplant.
Whole body replacement uses cloned or synthetic embryos with a neocortex knockout, creating non-sentient bodies for head or brain transplants that ensure compatibility and prevent rejection.
Cloned Non-Sentient Bodies
Body Transplant Process
01

Progressive brain replacement via stemcell-based tissue engineering.
Whole body replacement via cloned or synthetic embryo with neocortex knockout for head or brain transplant.
Progressive brain replacement uses stem cell-based tissue engineering to regenerate and restore neural function by gradually integrating lab-grown replacements.
Progressive Brain Replacement
02

Progressive brain replacement via stemcell-based tissue engineering.
Progressive brain replacement uses stem cell-based tissue engineering to regenerate and restore neural function by gradually integrating lab-grown replacements.
Progressive Brain Replacement
02

Total replacement of aged body parts with lab-grown young parts.
Total replacement of aged body parts involves using lab-grown, youthful tissue to regenerate limbs and other organs.
Limb regeneration
Xenotransplantation
Bioprinting
03

Total replacement of aged body parts with lab-grown young parts.
Total replacement of aged body parts involves using lab-grown, youthful tissue to regenerate limbs and other organs.
Limb regeneration
Xenotransplantation
Bioprinting
03
FOCUS AREAS / FOCUS AREAS / FOCUS AREAS
FOCUS AREAS / FOCUS AREAS / FOCUS AREAS


Progressive Brain Replacement
Replacement of aging brain tissue, minimizing disruption to cognitive function and allowing gradual replacement without loss of identity or memory.

Progressive Brain
Replacement of aging brain tissue, minimizing disruption to cognitive function and allowing gradual replacement without loss of identity or memory.


Body Transplant Process
Advancing the field of transplant surgery, our work focuses on refining surgical techniques for head and brain transplants while also pioneering innovations in spinal cord fusion

Body Transplant Process
Advancing the field of transplant surgery, our work focuses on refining surgical techniques for head and brain transplants while also pioneering innovations in spinal cord fusion


Limb Regeneration
Activation of stem cells and tissue scaffolding to initiate and guide the regrowth of complex tissues. By leveraging growth factors, gene editing, and bio-electricity, we aim to replicate the remarkable regenerative capabilities found in species like axolotls

Limb Regeneration
Activation of stem cells and tissue scaffolding to initiate and guide the regrowth of complex tissues. By leveraging growth factors, gene editing, and bio-electricity, we aim to replicate the remarkable regenerative capabilities found in species like axolotls


Cloned Non-Sentient Bodies
Developing and testing gene editing techniques for clone neocortex knockout, striving to achieve a near-zero false-negative knockout rate

Cloned Non-Sentient Bodies
Developing and testing gene editing techniques for clone neocortex knockout, striving to achieve a near-zero false-negative knockout rate


Bioprinting
Scaled production of bioprinted organs using organ-specific bioinks, with a strong focus on ensuring vascularization and seamless functional integration

Bioprinting
Scaled production of bioprinted organs using organ-specific bioinks, with a strong focus on ensuring vascularization and seamless functional integration


Xenotransplantation
Genetic modification of donor animals to prevent rejection and enhance compatibility, alongside developing protocols to induce immune tolerance in human recipients

Xenotransplantation
Genetic modification of donor animals to prevent rejection and enhance compatibility, alongside developing protocols to induce immune tolerance in human recipients
An In Vivo Platform for Rebuilding Functional Neocortical Tissue.
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Cephalic exchange transplantation in the monkey
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Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer
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Most advanced synthetic human embryo models yet spark controversy
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Several mutations that cause hydranencephaly have been identified.
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Jean Hebert | Replacement as the Surest, Fastest, and Cheapest Way to Beat Aging.
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PROJECTS IN DEVELOPMENT / PROJECTS IN DEVELOPMENT
SUBMIT A PROJECT PROPOSAL
If you have a project in the field of replacement and would like to apply for funding, please submit a proposal.
SUBMIT A PROJECT PROPOSAL
If you have a project in the field of replacement and would like to apply for funding, please submit a proposal.


